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. 2009 Nov;331(2):361–371. doi: 10.1124/jpet.109.156901

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© 2009 by the American Society for Pharmacology and Experimental Therapeutics

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Fig. 3. — Capsaicin pretreatment preserves ACh release from motor nerve endings against the inhibitory effects of BoNT/A. A, B, and C are representative trains of EPPs recorded at 70 Hz (left traces) and single EPPs at 1 Hz (right traces) for EDL muscles excised from control, + BoNT/A, and + CAP + BoNT/A-treated mice, respectively; preparations are dissected at 48 h after BoNT/A administration. D presents the percentage failure of EPP generation in response to neural stimulation at 70 Hz for the preceding three groups. Percent failure was calculated as 100 × [1 − (the number of EPPs during the 70 Hz train divided by 40)]; 40 is the number of supramaximal stimuli applied to the nerve.