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. 2009 Nov 6;5(11):e1000558. doi: 10.1371/journal.pcbi.1000558

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Bandara et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The mean of parameter variances dropped from 193.5 after the traditional experiment to 2.9 after the second optimized one. For comparison, parameter uncertainties were calculated for repetitions of the intuitive traditional experiment. (B) Parameter uncertainties after individual experiments were performed. (C) Normalized eigenvectors of the corresponding covariance matrices ordered in ascending length suggest that correlation between biological parameters was largely eliminated. (D) The ranges of the eigenvalue spectra of were consistently reduced.

Inline graphic — (A) The mean of parameter variances dropped from 193.5 after the traditional experiment to 2.9 after the second optimized one. For comparison, parameter uncertainties were calculated for repetitions of the intuitive traditional experiment. (B) Parameter uncertainties after individual experiments were performed. (C) Normalized eigenvectors of the corresponding covariance matrices ordered in ascending length suggest that correlation between biological parameters was largely eliminated. (D) The ranges of the eigenvalue spectra of were consistently reduced.