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. 2009 Nov 20;4(11):e7919. doi: 10.1371/journal.pone.0007919

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Rajaram et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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After entry into macrophages F. tularensis subsp. novicida escapes the phagosome, which leads to Fas up-regulation and recruitment of the DISC complex. This activates caspase-8 and caspase-3 leading to host-cell death. PI3K/Akt promotes phagosome-lysosome fusion and therefore limits intracellular bacterial growth and host-cell death. SHIP opposes the effects of the PI3K/Akt pathway.