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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2009 Sep 6;17(21):7593–7605. doi: 10.1016/j.bmc.2009.08.065

Scheme 2.

Scheme 2

i) Hg(tBuCOO)2, pivalic acid, 80 °C; ii) BH3-THF, then Boc2O, p-dioxane, 10% NaHCO3; iii) H2, Pd/C, MeOH/H2O/AcOH; iv) Fmoc-Arg(NO2)-OH, TFFH, HOAt, CH2Cl2/aq. NaHCO3; v) BH3-THF, −10 °C; vi) 20% piperidine, DMF, then 21, DIEA, CH3CN; vii) TFA, CH2Cl2.