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Role of MAP kinase signaling in endothelial surface P-selection. FACs analysis revealed that VEGF (10 ng/ml) or TGF-β1 (1 ng/ml) significantly decreased surface P-selectin on BAEC. Pharmacological inhibition of p38 prevented TGF-β-induced changes, whereas inhibition of JNK blocked VEGF modulation of BAEC surface P-selectin.
