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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Eur J Neurosci. 2009 Oct 12;30(8):1565–1575. doi: 10.1111/j.1460-9568.2009.06931.x

Fig. 2.

Fig. 2

Distribution of [11C]-cocaine superimposed on MRI atlas (a) for the isoflurane (b, n=3) and α-chloralose (c, n=3) used in the animals. Time activity of [11C]-cocaine binding in the somatosensory cortex of rat brains (d) and the time course of the ratio of [11C]-cocaine between the striatum and cerebellum (e). The shadow bars in d) represent the half-peak clearance of [11C]-cocaine from the brains. Peak uptake of [11C]-cocaine (t(PKmax)) occurred at 2.5 ± 1.1 min for ISO- and 4.0 ± 1.6 min for α-CHLOR-anesthetized animals; The half-peak clearance of cocaine from brain (t(PK1/2max)) was 15.8 ± 2.8 min for ISO- and 27.5 ± 0.6 min for α-CHLOR-anesthetized animals. The ¼ peak- clearance times (t(PK1/4Max)) were 22.9±5.6 min and 37.6±8.1 min, from animals anesthetized with isoflurane and α-chloralose, respectively.