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. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Eur J Neurosci. 2009 Oct 12;30(8):1565–1575. doi: 10.1111/j.1460-9568.2009.06931.x

Table 1.

Animal groups and experimental design

Group	Anesthetic	Detection probe	Measured parameters	Intravenous drug challenge
a1 (n=4)	Isoflurane	Optical A, B	CBF	Saline (0.9% NaCl, 0.1cc/100mg)
a2 (n=4)		Optical A, B	CBV, S_tO₂	Saline (0.9% NaCl, 0.1cc/100mg)
b1 (n=5)		Optical A, B	CBF	Cocaine hydrochloride (1mg/kg)
b2 (n=6)		Optical A, B	CBV, S_tO₂	Cocaine hydrochloride (1mg/kg)
b3 (n=3)		PET C	PK of [¹¹C]-cocaine	[¹¹C]-cocaine^†
c1 (n=4)	α–chloralose	Optical A, B	CBF	Saline (0.9% NaCl, 0.1cc/100mg)
c2 (n=4)		Optical A, B	CBV, StO2	Saline (0.9% NaCl, 0.1cc/100mg)
d1 (n=5)		Optical A, B	CBF	Cocaine hydrochloride (1mg/kg)
d2 (n=5)		Optical A, B	CBV, StO2	Cocaine hydrochloride (1mg/kg)
d3 (n=3)		PET C	PK of [¹¹C]-cocaine	[¹¹C]-cocaine^‡

^†

903 ± 347 μCi with a mass dose of 0.00039 ± 0.0002 mg/kg cocaine

^‡

713 ± 99 μCi with a mass dose of 0.0004 ± 0.00004 mg/kg cocaine