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. Author manuscript; available in PMC: 2010 Oct 20.
Published in final edited form as: Biochemistry. 2009 Oct 20;48(41):9775–9784. doi: 10.1021/bi900634e

Figure 2.

Figure 2

Binding affinity and potency of the truncated ACTH fragments at the wild-type hMC3R and hMC4R. Panel A and C show that the effects of the truncated ACTH fragments on 125I-NDP-α-MSH binding at hMC3R and hMC4R. Panel B and D show the effects of the truncated ACTH fragments on total cAMP accumulation at hMC3R and hMC4R (n ≥ 3; see Table 3 for Ki and EC50 values).