Figure 9.
The presence of IMI-CCAP in LG lowers the threshold MCN1 firing frequency for activating the gastric mill rhythm in a computational model. A, Modest MCN1 stimulation in the absence of CCAP did not activate the gastric mill rhythm. Note the small effect of GMI-MCN1 on the LG membrane potential. B, A slightly faster MCN1 stimulation frequency, without CCAP present, did elicit the gastric mill rhythm. C, The previously subthreshold MCN1 stimulation frequency did drive the gastric mill rhythm when IMI-CCAP was present in LG. Most hyperpolarized Vm (A–C): LG, −73 mV.