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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Biol Chem. 2009 Oct;390(10):965–976. doi: 10.1515/BC.2009.111

Figure 1. Hepatocytes are well equipped to maintain liver integrity.

Figure 1

When the liver receives an insult, hepatocytes activate specific intracellular programmes to induce PCD and proliferation. NF-κB plays an essential role in preventing TNFα-mediated hepatocyte death. In addition, NF-κB regulates important events that induce hepatocyte proliferation. Deregulation of these signalling pathways contribute to liver disease. Excessive hepatocyte death is associated with hepatitis and liver failure. Induction of hepatocyte PCD promotes also compensatory proliferation, which can lead to the development of HCC.