Table 1.

Characteristics of CF in responders and non-responders at two years of age

	Responder	Non-Responder	P-value
N (%)	41 (65%)	22 (35%)
Age of diagnosis (mo)
mean ± SD	4.0 ± 6.2	2.6 ± 3.2	0.39
Median	1.8	1.7	0.44
No. (%) diagnosed by newborn screening	28 (68%)	14 (64%)	0.71
Growth indices
Weight-for-age Z-score (WTz)	0.28 ± 0.93	−1.23 ± 0.81	<0.0001
Height-for-age Z-score (HTz)	0.06 ± 0.89	−1.03 ± 0.79	<0.0001
BMI Z-score (BMIz)	0.43 ± 0.92	−0.38 ± 0.90	0.001
Shwachman-Kulczycki scores*
Activity	24.8 ± 0.9	24.5 ± 1.2	0.27
Physical Exam	24.2 ± 1.7	23.1 ± 2.8	0.05
Growth	24.1 ± 2.1	21.1 ± 3.9	0.0003
Chest radiographic score	22.7 ± 1.9	22.0 ± 2.1	0.24
Total score	95.7 ± 3.8	90.7 ± 7.3	0.001
Parent-reported cough and wheezing
Presence of daytime coughing, N (%)	4 (10%)	6 (27%)	0.25
Presence of nighttime coughing, N (%)	7 (17%)	8 (36%)	0.09
Presence of wheezing, N (%)	2 (5%)	2 (9%)	0.61
Brasfield and Wisconsin CXR scores†
Brasfield score	21.1 ± 1.5	20.5 ± 2.2	0.16
Wisconsin score	5.9 ± 3.5	8.0 ± 5.8	0.08
Respiratory Infection‡
Positive SA, N (%)	7 (18%)	6 (27%)	0.37
Positive PA, N (%)	6 (15%)	6 (27%)	0.24

^*1 responder did not have Shwachman-Kulczycki score at age 2

^†7 responders and 1 non-responder did not have Brasfield and Wisconsin CXR scores at age 2

^‡1 responder did not have respiratory infection data at age 2