Fig. 3.
Reduced depressant effect and faster recovery from motor incoordinating effect of ethanol in Trpv1 knockout (-/-) mice. A. Duration of LORR produced by 3.2 and 3.4 g/kg ethanol (EtOH) was significantly reduced in mutant mice Trpv1 (-/-) compared to wild type (WT). Values are mean ± SEM, n = 10-14 for each dose and genotype; *p < 0.05, **p < 0.01, significant difference compared to wild type for same dose of ethanol (Student’s t-test). B. Mutant mice showed faster recovery from the motor impairing effect of ethanol (2 g/kg) compared to wild type mice. n = 10 per genotype.