. Author manuscript; available in PMC: 2010 Apr 1.

Published in final edited form as: Eur J Pharmacol. 2009 Apr 1;607(1-3):251–257. doi: 10.1016/j.ejphar.2009.01.042

Table 1.

Serotonin concentrations and net hepatic balance in conscious 42-h-fasted dogs given saline, or a low or high dose escitalopram infusion into the hepatic portal vein

		Experimental Period
Group	Basal Period	Period 1	Period 2
5-HT Levels in Liver (ng/mg protein)
SAL	N/A	N/A	543±141
L-ESC	N/A	N/A	799±208
H-ESC	N/A	N/A	908±72^a
Arterial Blood 5-HT (μg/L)
SAL	1140±283	1054±238	968±250
L-ESC	835±176	835±165	702±126
H-ESC	805±203	766±217	728±172
Portal Blood 5-HT (μg/L)
SAL	1235±322	1139±243	933±200
L-ESC	873±149	780±126	733±123
H-ESC	901±240	834±202	730±173
Hepatic Blood 5-HT (μg/L)
SAL	1268±299	1150±220	1041±226
L-ESC	889±131	861±138	694±113
H-ESC	945±230	861±175	769±197
Net Hepatic 5-HT Balance (μg/kg/min)
SAL	1.5±2.0	1.0±0.6	2.6±1.5
L-ESC	0.7±1.8	1.8±1.1	−0.7±1.4
H-ESC	2.0±1.8	0.7±1.3	0.9±1.3

Data are mean ± S.E.M.. n=6 dogs in each group

Negative values for balance data indicate net hepatic uptake

Significant statistical difference (P<0.05) from the saline group