Table 4.
Average lactate, glycerol and non-esterified fatty acid concentrations and net hepatic balances during the basal and experimental periods in conscious 42-h-fasted dogs given saline, or a low or high dose escitalopram infusion into the hepatic portal vein
| Experimental Period |
|||
|---|---|---|---|
| Group | Basal Period | Period 1 | Period 2 |
| Arterial Blood Lactate (μmol/L) | |||
| SAL | 327±58 | 673±84 | 783±81 |
| L-ESC | 395±32 | 934±98 | 855±73 |
| H-ESC | 551±90 | 1025±192 | 986±103 |
| Net Hepatic Lactate Balance (μmol/kg/min) | |||
| SAL | −7.3±1.1 | 3.5±4.3 | 3.0±2.8 |
| L-ESC | −6.6±0.9 | 6.8±1.6 | 3.6±1.4 |
| H-ESC | −5.2±1.5 | 4.1±1.5 | 3.5±1.8 |
| Arterial Blood Glycerol (μmol/L) | |||
| SAL | 82±14 | 43±11 | 34±15 |
| L-ESC | 97±9 | 34±5 | 24±4 |
| H-ESC | 98±7 | 46±10 | 31±7 |
| Net Hepatic Glycerol Uptake (μmol/kg/min) | |||
| SAL | 1.8±0.4 | 1.0±0.4 | 0.6±0.3 |
| L-ESC | 2.1±0.3 | 0.5±0.1 | 0.5±0.1 |
| H-ESC | 1.4±0.2 | 0.7±0.1 | 0.6±0.2 |
| Arterial Plasma Non-esterified Fatty Acid (μmol/L) | |||
| SAL | 803±114 | 108±11 | 90±18 |
| L-ESC | 909±75 | 133±17 | 96±14 |
| H-ESC | 1027±57 | 138±20 | 100±14 |
| Net Hepatic Non-esterified Fatty Acid Uptake (μmol/kg/min) | |||
| SAL | 4.4±1.5 | 0.2±0.1 | 0.1±0.1 |
| L-ESC | 3.2±0.4 | 0.4±0.1 | 0.2±0.1 |
| H-ESC | 3.0±0.5 | 0.4±0.1 | 0.2±0.1 |
Data are mean ± S.E.M.. n=11 dogs in the saline group (SAL), n=6 in the group that received escitalopram at 2 μg/kg/min (L-ESC) and n=7 in the group that received escitalopram at 8 μg/kg/min (H-ESC)
All values in each group during the experimental period were significantly different (P<0.05) from the basal period. Negative values for balance data indicate net hepatic uptake