Skip to main content
. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2009;48(32):5860–5863. doi: 10.1002/anie.200902509

Scheme 2.

Scheme 2

Failure of the original synthetic plan. Reagents and conditions: a) 5 (1.0 equiv), 7 (1.5 equiv), CuI (0.4 equiv), Pd2(dba)3 (0.1 equiv), Cu (10.0 equiv), DMSO, 65 °C, 2.5 h, 83 %; b) 12 (0.2 equiv), Et3N (2.0 equiv), CH2Cl2, 42 °C, 18 h, 76 %, ca. 1:1.5 benzoin:Stetter. dba = dibenzylideneacetone.