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. 2009 Jan 14;29(2):483–492. doi: 10.1523/JNEUROSCI.3704-08.2009

Figure 4.

Figure 4.

NRF-1 overexpression in primary neurons significantly increased mRNA levels for Grin1, Grin2b, COX2, and COX6c genes and rescued them from TTX-induced suppression. NRF-1, Grin1, Grin2b, COX2, COX6c, Grin2a, and Grin3a mRNA levels (A–G) were all reduced by TTX compared with controls, indicating a generalized depressive effect of TTX on neurons. Overexpression of NRF-1 significantly increased transcript levels of NRF-1, Grin1, Grin2b, COX2, and COX6c, but not of Grin2a and Grin3a. Overexpression of NRF-1 was able to rescue NRF-1, Grin1, Grin2b, COX2, and COX6c but not Grin2a and Grin3a transcripts from being downregulated by TTX. (n = 6 for each group). All *p values were compared with empty vectors (*p < 0.05, **p < 0.01, ***p < 0.001). All #p values were compared with empty vector + TTX (#p < 0.05, ##p < 0.01, ###p < 0.001), and all Xp values were compared with NRF-1 overexpression (Xp < 0.05, XXXp < 0.001).