Figure 4.

Distinct sensitivity to leptin of glucocorticoid modulation of glutamate release and GABA release. A, Normalized running average (1 min bin width) of mPSC frequency (Freq). Leptin (10 nm) blocked the Dex (1 μm)-induced decrease in mEPSC frequency (n = 5), but failed to block the Dex-induced increase in mIPSC frequency (n= 6). B, Summary histogram of mean mIPSC frequency response to leptin and Dex. Leptin had no effect on either the basal mIPSC frequency or the Dex-induced increase in mIPSC frequency.