Table 2.

Effect of I⁻ restriction on serum I⁻ in wild-type and pendrin null mice

	Water Intake, ml/day	Total I−, μg/ml	Inorganic I−, μg/ml	Thyroid-Stimulating Hormone, mU/l
Wild-type	9	7.0±0.3 (n = 4)	3.1±0.3 (n = 4)	22±2 (n = 5)
Pendrin null	9	5.9±0.4 (n = 3)	1.5±0.1*(n = 3)	21±6 (n = 5)

Values are means ± SE. Mice were given the synthetic, low I⁻ diet (0.9 mg I⁻/day, series 1).

^*P < 0.05.