Table 3.

Levels of estrogens and SHBG by age, BMI, and WHR among placebo-treated women

	Age (yr)a			P for trend	BMI (kg/m2)b			P for trend	WHR (%)c			P for trend
	<60	60–64	≥65		<25	25–29	≥30		<0.80	0.80–0.83	>0.83
Univariate analysis
n	36	16	37		22	32	35		31	29	29
E2	22.2 (1.7)	18.7 (2.6)	21 (1.7)	0.94	18.6 (2.2)	19.9 (1.8)	23.7	0.05	19.7 (1.8)	20.2 (1.9)	23.5 (1.9)	0.16
FE2	0.6 (0.04)	0.5 (0.1)	0.6 (0.04)	0.35	0.5 (0.1)	0.5 (0.04)	0.7 (0.04)	0.001	0.53 (0.04)	0.57 (0.05)	0.65 (0.05)	0.06
E1	50.1 (7.1)	40.3 (10.6)	49.6 (7.0)	0.88	47.5 (9.1)	47.2 (7.5)	49.4 (7.2)	0.85	46.4 (7.6)	42.6 (7.8)	55.5 (7.8)	0.42
SHBG	33.0 (3.0)	40.9 (4.5)	38.0 (3.0)	0.18	44.3 (3.7)	38.4 (3.1)	29.8 (2.9)	0.002	42.4 (3.2)	34.8 (3.3)	31.9 (3.3)	0.02
Multivariate analysis
n	36	16	37		22	32	35		31	29	29
E2	21.5 (1.7)	18.8 (2.5)	20.9 (1.7)	0.94	18.4 (2.2)	19.6 (1.8)	23.2 (1.8)	0.06	19.2 (1.9)	20.02 (1.9)	23.1 (2.03)	0.13
FE2	0.6 (0.04)	0.5 (0.1)	0.6 (0.04)	0.35	0.5 (0.1)	0.5 (0.04)	0.7 (0.04)	0.002	0.51 (0.01)	0.56 (0.04)	0.64 (0.05)	0.03
E1	49.9 (7.3)	40.4 (10.7)	49.6 (7.1)	0.88	46.5 (9.2)	45.9 (7.8)	47.6 (7.6)	0.85	45.2 (7.9)	42.0 (8.0)	53.9 (8.4)	0.41
SHBG	34.9 (3.0)	40.8 (4.4)	38.5 (2.9)	0.18	44.5 (3.8)	38.9 (3.2)	30.8 (3.1)	0.003	43.8 (3.3)	34.9 (3.3)	32.3 (3.5)	0.01

Data are expressed as mean (se). E2, Total estradiol; FE2, free estradiol. 

Multivariate models with: 

^aage adjusted for BMI; 

^bBMI adjusted for age; 

^cWHR adjusted for age.