Table 4.

Levels of estrogens and SHBG by age, BMI, and WHR among E2-treated women

	Age (yr)a			P for trend	BMI (kg/m2)b			P for trend	WHR (%)c			P for trend
	<60	60–65	≥65		<25	25–29	≥30		<0.80	0.80–0.83	>0.83
Univariate analysis
n	38	25	28		26	31	34		29	28	34
E2	65.6 (4.5)	68.3 (5.3)	72.2 (5.7)	0.37	59.7 (5.5)	64.5 (4.7)	78.1 (4.7)	0.01	70.4 (5.3)	69.4 (5.3)	65.4 (4.8)	0.91
FE2	1.6 (0.1)	1.6 (0.1)	1.6 (0.1)	0.93	1.4 (0.1)	1.5 (0.1)	1.9 (0.1)	0.002	1.59 (0.12)	1.59 (0.12)	1.60 (0.11)	0.59
E1	284.3 (27.2)	322.7 (31.1)	336.5 (34.2)	0.21	308.0 (34.3)	290.5 (29.3)	331.2 (28.8)	0.55	341.6 (31)	319.2 (31.5)	276.3 (28.6)	0.90
SHBG	53.8 (3.9)	61.4 (4.4)	61.3 (4.8)	0.19	65.7 (4.9)	55.7 (4.1)	55.6 (4.0)	0.13	67.4 (4.9)	58.1 (4.3)	50.7 (3.9)	0.01
Multivariate analysis
n	38	29	24		26	31	34		29	28	34
E2	65.0 (4.4)	66.9 (5.6)	71.2 (5.2)	0.37	60.6 (5.6)	64.4 (4.7)	78.3 (4.8)	0.01	70.7 (5.4)	70 (5.4)	65.1 (5.0)	0.46
FE2	1.6 (0.1)	1.5 (0.1)	1.6 (0.1)	0.93	1.4 (0.1)	1.5 (0.1)	1.8 (0.1)	0.002	1.59 (0.1)	1.60 (0.1)	1.59 (0.1)	0.92
E1	283.2 (27.3)	320.9 (33.7)	337.7 (32.4)	0.21	316.3 (34.9)	291.1 (29.3)	334.0 (29.0)	0.62	345.3 (31)	322.2 (31.7)	278.4 (29.6)	0.11
SHBG	54.2 (3.8)	62.5 (4.7)	62.5 (4.5)	0.19	66.9 (4.9)	55.9 (4.1)	56.3 (4.0)	0.12	67.9 (4.3)	58.4 (4.3)	51.5 (4.1)	0.005

Data are expressed as mean (se). E2, Total estradiol; FE2, free estradiol. 

Multivariate models with: 

^aage adjusted for BMI; 

^bBMI adjusted for age; 

^cWHR adjusted for age.