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. 2009 Oct 22;94(11):4152–4161. doi: 10.1210/jc.2009-1340

Table 1.

Summary of test measures and outcome variables

Cognitive/affective domain and measure Outcome variable Score range Predicted treatment effect
Verbal knowledge Total correct−one third number ≤50
 PMA vocabulary  incorrect No difference
Verbal fluency No difference
 Letter fluency (F, A, S) Total correct 0+
 Semantic fluency (vegetables, fruits) Total correct 0+
Figural memory Total figures with errors 0–26 CEE fewer errors over time
BVRT
Verbal memory Total of 3 list A trials (immediate recall) 0–48 CEE higher scores over time
CVLT Total for list B (interference) 0–16
Total for short-delay free recall 0–16
Total for long-delay free recall 0–16
Attention and working memory CEE higher scores over time
 Digits forward Total correct trials 0–14
 Digits backward Total correct trials 0–14
Spatial rotational ability Total correct−total incorrect ≤160 CEE lower over time
 Card rotations
Fine motor speed CEE higher scores over time
 Finger tapping dom Total score 0+
 Finger tapping nondom Total score 0+
Affect
PANAS
 PANAS positive Mean score 1–5
 PANAS negative Mean score 1–5 CEE lower over time
Geriatric depression scale Total score 0–15 CEE lower over time

Descriptions and references for tests of cognition and affect are detailed elsewhere (5). Higher BVRT scores reflect poorer performance. Tests in bold are those predicted to be the most sensitive to treatment effects based on prior studies. PMA, Primary mental abilities; BVRT, Benton Visual Retention Test; CVLT, California Verbal Learning Test; dom, dominant hand; nondom, nondominant hand; PANAS, Positive and Negative Affect Schedule. 

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