Table 1.
Baseline comparisons of demographic and biochemical parameters in healthy participants 18–45 yr old and older than 60 yr (n = 325)
| 18–45 yr old | Older than 60 yr | Pa | Older than 60 yr (GFR >90) | Older than 60 yr (GFR 30–60) | Pb | Pc | |
|---|---|---|---|---|---|---|---|
| Age (yr) | 30 ± .7 | 80 ± .7 | 0.000 | 74 ± 1 | 85 ± 1 | 0.000 | 0.000 |
| BMI (kg/m2) | 24 ± 0.5 | 28 ± 0.7 | 0.000 | 27 ± 1 | 29 ± 2 | 0.505 | 0.002 |
| Systolic BP (mm Hg) | 114 ± 2 | 128 ± 2 | 0.000 | 126 ± 3 | 123 ± 9 | 0.739 | 0.108 |
| Diastolic BP (mm Hg) | 66 ± 1 | 69 ± 2 | 0.108 | 70 ± 2 | 67 ± 4 | 0.518 | 0.716 |
| Triglycerides (mg/dl) | 65 ± 5 | 111 ± 4 | 0.000 | 105 ± 10 | 116 ± 7 | 0.348 | 0.000 |
| HDL cholesterol (mg/dl) | 66 ± 2 | 53 ± 1 | 0.000 | 60 ± 3 | 46 ± 2 | 0.000 | 0.000 |
| LDL cholesterol (mg/dl) | 93 ± 4 | 113 ± 2 | 0.000 | 106 ± 3 | 110 ± 4 | 0.441 | 0.004 |
| Glucose (mg/dl) | 73 ± 1 | 84 ± 2 | 0.000 | 84 ± 3 | 82 ± 2 | 0.556 | 0.012 |
| Creatinine clearance (ml/min) | 119 ± 4 | 86 ± 3 | 0.000 | 109 ± 2 | 47 ± 3 | 0.000 | 0.000 |
| Urinary protein (mg/d) | 100 ± 8 | 98 ± 9 | 0.924 | 116 ± 14 | 60 ± 8 | 0.001 | 0.052 |
BMI, Body mass index; BP, blood pressure; LDL, low-density lipoprotein; HDL, high-density lipoprotein.
a
Statistically significant difference between healthy participants 18–45 yr old and those older than 60 yr.
b
Statistically significant difference between healthy participants older than 60 yr with GFR greater than 90 ml/min and those with GFR between 30 and 60 ml/min.
c
Statistically significant difference between healthy participants 18–45 yr old and those older than 60 yr with GFR 30–60 ml/min.