Table 2.
Univariate and multivariate analysis with nevirapine AUC as the dependent variable
| Univariate |
Multivariate |
||
|---|---|---|---|
| Variables | P value | coefficient | P value |
| Age | 0.870 | — | — |
| Weight | 0.015 | −0.407 | 0.031 |
| Creatinine | 0.063 | 19.00 | 0.027 |
| SGPT | 0.220 | — | — |
| HIV-RNA viral load | 0.461 | — | — |
| CD4 cell count | 0.598 | — | — |
| CYP2B6 | |||
| g.3003T>C (rs8100458) | 0.576 | — | — |
| c.516G>T (rs3745274) | 0.054 | — | — |
| c.785A>G (rs2279343) | 0.201 | — | — |
| g.18492T>C (rs2279345) | 0.041 | 24.47 | 0.009 |
| g.21563C>T (rs8192719) | 0.019 | — | — |
| TGATC haplotype | 0.003 | −33.73 | 0.001 |
| CYP3A4 | |||
| g.–486G>A | — | — | — |
| g.–392A>G (rs2740574) | — | — | — |
| c.878T>C (rs28371759) | 0.869 | — | — |
| ABCB1 | |||
| c.3435C>T (rs1045642) | 0.788 | — | — |