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Heterotrimer complex of Klotho, FGF23, and FGFR1c. Klotho, FGF23, and FGFR1c make a heterotrimer complex in order to transmit the signal of FGF23 to target organs. Therefore, Klotho seems to be necessary for FGF23 signaling. N: N-terminus of FGF23 protein; C: C-terminus of FGF23 protein.
