Table 2. Similarity of Anopheles funestus proteins to best matching homologues of An. gambiae, Aedes aegypti, Culex quinquefasciatus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana and Saccharomyces cerevisae.

		An. gambiae	Ae. aegypti	C. quinquefasciatus	D. melanogaster	C. elegans	A. thaliana	S. cerevisae
Functional Class	N	Mean (SE)	Mean (SE)	Mean (SE)	Mean (SE)	Mean (SE)	Mean (SE)	Mean (SE)
Proteasome	7	0.95(0.03)	0.94 (0.02)	0.86 (0.04)	0.80(0.03)	0.54 (0.06)	0.51 (0.05)	0.41 (0.06)
Detoxification	10	0.94(0.02)	0.74 (0.03)	0.68 (0.05)	0.56 (0.04)	0.26 (0.05)	0.25 (0.04)	0.19 (0.04)
Transcription	9	0.93 (0.10)	0.81 (0.11)	0.72 (0.10)	0.62 (0.12)	0.24 (0.05)	0.28 (0.07)	0.22 (0.04)
Signal transduction	26	0.93 (0.04)	0.82 (0.05)	0.75 (0.05)	0.61 (0.05)	0.36 (0.05)	0.27 (0.04)	0.25 (0.04)
Protein synthesis	49	0.92 (0.02)	0.86 (0.02)	0.78 (0.03)	0.78 (0.03)	0.57 (0.03)	0.56 (0.03)	0.52 (0.03)
Energy metabolism	54	0.91 (0.02)	0.84 (0.02)	0.77 (0.02)	0.68 (0.02)	0.40 (0.03)	0.29 (0.02)	0.26 (0.02)
Metabolism	31	0.89 (0.03)	0.73 (0.04)	0.70 (0.04)	0.58 (0.04)	0.36 (0.03)	0.24 (0.03)	0.21 (0.03)
Protein modification	37	0.88 (0.03)	0.79 (0.03)	0.73 (0.03)	0.57 (0.04)	0.35 (0.03)	0.28 (0.03)	0.23 (0.03)
Cytoskeletal	32	0.87 (0.05)	0.76 (0.05)	0.64 (0.05)	0.62 (0.05)	0.41 (0.06)	0.33 (0.05)	0.32 (0.05)
Transporters and storage	10	0.85 (0.05)	0.77 (0.06)	0.72 (0.05)	0.50 (0.08)	0.21 (0.07)	0.19 (0.06)	0.13 (0.03)
Protein export	16	0.84 (0.07)	0.75 (0.07)	0.71 (0.06)	0.67 (0.05)	0.44 (0.05)	0.32 (0.05)	0.24 (0.04)
Nuclear regulation	5	0.83 (0.05)	0.78 (0.15)	0.70 (0.15)	0.49 (0.05)	0.20 (0.05)	0.21 (0.04)	0.20 (0.04)
Extracellular structures	34	0.80 (0.06)	0.59 (0.06)	0.48 (0.04)	0.36 (0.03)	0.16 (0.01)	0.16 (0.01)	0.15 (0.01)
Unknown conserved	103	0.72 (0.03)	0.52 (0.03)	0.45 (0.02)	0.33 (0.02)	0.18 (0.01)	0.15 (0.01)	0.13 (0.01)
Immunity	16	0.70 (0.06)	0.47 (0.05)	0.47 (0.05)	0.31 (0.04)	0.20 (0.02)	0.16 (0.02)	0.15 (0.02)
Salivary	41	0.61 (0.03)	0.27 (0.03)	0.24 (0.03)	0.19 (0.02)	0.13 (0.01)	0.13 (0.01)	0.12 (0.01)
Unknown	21	0.16 (0.01)	0.19 (0.01)	0.17 (0.01)	0.16 (0.01)	0.17 (0.01)	0.16 (0.01)	0.15 (0.01)
Transposable element	3	0.08 (0.00)	0.15 (0.06)	0.13 (0.02)	0.08 (0.01)	0.11 (0.03)	0.07 (0.010	0.07 (0.010)

N, number of An. funestus proteins compared per functional class; Mean, average normalized blast scores; SE, standard error of the mean.