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. 2009 Oct 19;4:217–225. doi: 10.2147/ijn.s7653

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© 2009 Yudoh et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Representative images of the joint damage at each time point in arthritis model rats. A) After four weeks of treatment, there was a tendency in the group treated with phosphate-buffered saline (PBS) towards a more severe degree of synovitis than in the group treated with C60 (10.0 μM). B) At six weeks after immunization, intraarticular treatment with C60 inhibited the infiltration of inflammatory cells, synovial hyperplasia, and bone resorption by multinucleated osteoclastic cells in the ankle joints of arthritis model rats, whereas the control joints that was treated with PBS showed more severe damage. C) At the eight-week time point, all ankle joints that had been treated with PBS showed severe joint destruction and bony ankylosis. In contrast, inhibitory effects were observed following administration of C60 in the C60-treated group.

Representative images of the joint damage at each time point in arthritis model rats. A) After four weeks of treatment, there was a tendency in the group treated with phosphate-buffered saline (PBS) towards a more severe degree of synovitis than in the group treated with C60 (10.0 μM). B) At six weeks after immunization, intraarticular treatment with C60 inhibited the infiltration of inflammatory cells, synovial hyperplasia, and bone resorption by multinucleated osteoclastic cells in the ankle joints of arthritis model rats, whereas the control joints that was treated with PBS showed more severe damage. C) At the eight-week time point, all ankle joints that had been treated with PBS showed severe joint destruction and bony ankylosis. In contrast, inhibitory effects were observed following administration of C60 in the C60-treated group.