Table 3.
Associations of Histological Lesions with Presence of Significant Fibrosis (Stage ≥2)
| Factor | Fibrosis 2/3 (n = 48) |
Fibrosis 0/1 (n = 60) |
P Value* |
|---|---|---|---|
| Steatosis amount | 0.17 | ||
| 0 | 3 (6.3) | 2 (3.3) | |
| 1 | 13 (27.1) | 27 (45.0) | |
| 2 | 18 (37.5) | 19 (31.7) | |
| 3 | 14 (29.2) | 12 (20.0) | |
| Steatosis type | 0.63 | ||
| Macro | 40 (83.3) | 47 (79.7) | |
| Mixed | 8 (16.7) | 12 (20.3) | |
| Zone | 0.061 | ||
| One | 5 (10.6) | 5 (8.8) | |
| Three | 6 (12.8) | 19 (33.3) | |
| Azonal | 17 (36.2) | 11 (19.3) | |
| Panacinar | 19 (40.4) | 22 (38.6) | |
| Ballooning | 0.065 | ||
| 0 | 9 (18.8) | 18 (30) | |
| 1 | 25 (52.1) | 33 (55) | |
| 2 | 14 (29.2) | 9 (15) | |
| Lobular Inflammation | 0.027 | ||
| 0 | 1 (2.1) | 8 (13.3) | |
| 1 | 25 (52.1) | 34 (56.7) | |
| 2 | 18 (37.5) | 16 (26.7) | |
| 3 | 4 (8.3) | 2 (3.3) | |
| Portal Inflammation | 0.025 | ||
| 0 | 4 (8.3) | 13 (21.7) | |
| 1 | 35 (72.9) | 42 (70.0) | |
| 2 | 9 (18.8) | 5 (8.3) | |
| Z3PSF | 38 (80.9) | 16 (26.7) | <0.001 |
| Mallory bodies | 9 (19.2) | 4 (6.7) | 0.050 |
| Megamitochondria | 2 (4.2) | 3 (5.0) | 0.99 |
| Acidophil bodies | 12 (27.9) | 10 (17.9) | 0.23 |
| NAS | 0.005 | ||
| 0–2 | 1 (2.1) | 11 (18.3) | |
| 3,4 | 19 (39.6) | 29 (48.3) | |
| ≥5 | 28 (58.3) | 20 (33.3) |
Values are expressed as n (%).
Abbreviation: Z3PSF, zone 3 perisinusoidal fibrosis.
*
P values correspond to Wilcoxon rank sum tests for continuous factors and ordinal scores, Pearson's chi-square test for megamits and NAS, and Fisher's exact test otherwise. Boldface indicates statistically significant values.