Table 2.

Parameters of Boltzmann fits of K⁺ current activation and inactivation before and after addition of substance P (SP) or phorbol 12, 13-dibutyrate (PDBu) in CAPS-responsive and unresponsive phasic neurons.

	ACTIVATION	INACTIVATION	ACTIVATION	INACTIVATION	ACTIVATION	INACTIVATION
Phasic, CR	control (n=62)	control (n=62)	SP (n=13)	SP (n=13)	PDBu (n=10)	PDBu (n=10)
LT, A1	0.53 ± 0.03	0.74 ± 0.05	0.20 ± 0.01**	0.33 ± 0.06**	0.18 ± 0.05**	0.36 ± 0.12**
k1	1.1 ± 2.1	19 ± 6	1.0 ± 0.4NS	31 ± 9NS	1.0 ± 0.3NS	21 ± 3NS
V10.5	−34.8 ± 0.5	−71 ± 3	−21.8 ± 0.3*	−82 ± 2 NS	−33.6 ± 4.0NS	−75 ± 15*
HT, A2	0.47 ± 0 .03	0.26 ± 0.04	0.34 ± 0.04**	0.24 ± 0.09NS	0.19 ± 0.07**	0.35 ± 0.17NS
k2	1.9 ± 6.0	8 ± 5	1.2 ± 0.2NS	14 ± 3*	1.6 ± 0.4NS	9 ± 3 NS
V20.5	−9.3 ± 0.3	−39 ± 4	−8.9 ± 0.2NS	−39 ± 4 NS	−8.6 ± 0.4NS	−38 ± 3 NS
Phasic, CU	control (n=44)	control (n=44)	SP (n=14)	SP (n=14)	PDBu (n=7)	PDBu (n=7)
LT, A1	0.62 ± 0.07	0.59 ± 0.09	0.23 ± 0.02**	0.12 ± 0.06 **	0.32 ± 0.01*	0.20 ± 0.06*
k1	4.4 ± 0.8	13 ± 6	3 ± 2NS	9 ± 7NS	4.3 ± 0.2NS	8 ± 4NS
V10.5	−17 ± 1	−71 ± 7	−20 ± 1NS	−92 ± 8NS	−13.6 ± 0.3NS	−99 ± 5NS
HT, A2	0.38 ± 0.07	0.41 ± 0.04	0.20 ± 0.02*	0.39 ± 0.05NS	0.11 ± 0.01**	0.40 ± 0.06NS
k2	4 ± 1	7 ± 5	2.1 ± 0.7NS	11 ± 2NS	1.9 ± 0.7NS	11 ± 3NS
V20.5	7 ± 2	−37 ± 6	4 ± 1NS	-47 ± 3NS	11 ± 1NS	−44 ± 3NS

Parameters for Boltzmann fits of low threshold activated and hyperpolarized voltage inactivating currents (A_LT and A1, k1, V1) and high threshold activated and depolarized voltage inactivating K⁺ current (A_HT and A2, k2, V2) for the activation and inactivation curves were determined as explained in Methods. The smooth curves shown in Fig. 3 were fitted with these values. Averages; SEM; t-test relative to values in control experiments, 2 tailed, unequal variance, level of significance: NS-not significant

^*P<0.05, or

^**P<0.001.