Table 2.
Penetrance and 95% Confidence Interval Estimates.
| Group | Age 30 (95% CI) | Age 50 (95% CI) | Age 70 (95% CI) |
| Any HNPCC cancer (Weibull) | |||
| Male Carrier | 9.1 (6.0, 17.9) | 70.5 (59.1, 87.7) | 98.2 (93.8, 99.9) |
| Female Carrier | 6.1 (3.8, 11.6) | 55.3 (42.8, 73.1) | 92.8 (82.4, 99.1) |
| Male Non-carrier | 1.0 (0.0, 1.6) | 11.9 (0.2, 20.0) | 33.9 (0.5, 53.6) |
| Female Non-carrier | 0.1 (0.0, 1.4) | 1.5 (0.1, 18.2) | 4.7 (0.4, 49.8) |
| CRC (Log-logistic) | |||
| Male Carrier | 11.1 (3.9, 19.9) | 62.2 (38.4, 73.8) | 84.5 (67.3, 91.3) |
| Female Carrier | 1.4 (0.6, 3.7) | 16.1 (8.9, 30.5) | 38.9 (24.2, 62.1) |
| Male Non-carrier | 0.3 (0.0, 1.6) | 4.1 (0.6, 16.2) | 12.5 (2.0, 39.8) |
| Female Non-carrier | 0.0 (0.0, 0.3) | 0.5 (0.1, 2.9) | 1.6 (0.3, 9.3) |
| EC (Log-logistic) | |||
| Female Carriers | 0.7 | 37.1 | 82.4 |
| Female Non-carriers | 0.0 | 0.0 | 0.0 |
Penetrance estimates (percent) at ages 30, 50 and 70 by carrier status and sex, with corresponding 95% confidence intervals. Estimates based on the specified hazard function for age at diagnosis of any hereditary nonpolyposis colorectal cancer (any HNPCC cancer), colorectal cancer (CRC) and endometrial cancer (EC)