Table 3.

Final proportions of cells (% of the total) after 13 years

	Uninfected cells		Infected cells
	Untransduced	Transduced	Untransduced	Transduced
Scenario				m = 0	m = 1	m = 2
1	1.3	63.5	35.1	0.1	0.005	0.0003
2	0.7	61.8	35.2	2.4	0.08	0
3	0.1	25.7	38.2	35.6	0.5	0
4	1.2	63.5	35.0	0.3	0.01	0
5	0.9	62.6	35.1	1.4	0.04	0.0003
6	0.6	61.5	35.1	2.7	0.08	0
7	0.4	59.8	35.4	4.3	0.1	0.001

The percentage of untransduced and transduced cells that are uninfected and infected after 5000 days (13 years) of modeling. The resistance profiles for the transduced cells that are infected are also shown, divided into the percentage of total cells infected with wildtype virus (m = 0) and virus containing mutations that confer complete resistance to either 1 (m = 1) or 2 shRNAs (m = 2). n.b. we observed no strains that developed resistance to more than 2 shRNAs.