Table 2. Association of AURKA F31I with breast cancer risk1.
| 0 or 1 copy Ile allele | 2 copies Ile allele | |||||||
|---|---|---|---|---|---|---|---|---|
| Group | Unaffected | Affected | Person Years | Unaffected | Affected | Person Years | HR (95% CI) All cases | HR (95% CI)* Incident cases |
| Overall | 3128 | 3696 | 296122 | 175 | 188 | 15793 | 0.91 (0.77-1.06) | 0.84 (0.65-1.08) |
| By mutation status | ||||||||
| BRCA1 | 2237 | 2460 | 200406 | 129 | 120 | 10754 | 0.90 (0.75-1.08) | 0.90 (0.66-1.22) |
| BRCA2 | 893 | 1245 | 96110 | 46 | 68 | 5039 | 0.93 (0.67-1.29) | 0.67 (0.44-1.03) |
| By menopausal status | ||||||||
| Pre-menopausal | 1935 | 2049 | 242208 | 111 | 106 | 12834 | 0.84 (0.69-1.03) | 0.83 (0.60-1.15) |
| Post-menopausal | 1193 | 1647 | 53914 | 64 | 82 | 2959 | 0.96 (0.75-1.23) | 0.77 (0.51-1.16) |
| By oophorectomy status | ||||||||
| No | 1772 | 2318 | 201303 | 101 | 107 | 10474 | 0.85 (0.69-1.05) | 0.82 (0.58-1.15) |
| Yes | 510 | 160 | 3793 | 28 | 9 | 213 | 1.10 (0.56-2.18) | 1.03 (0.39-2.78) |
| Missing | 846 | 1218 | 91026 | 46 | 72 | 5106 | 0.97 (0.75-1.26) | 0.86 (0.55-1.34) |
| By study site | ||||||||
| MAGIC | 559 | 423 | 41554 | 29 | 20 | 2002 | 1.02 (0.63-1.67) | |
| GEMO | 347 | 597 | 40913 | 13 | 39 | 2266 | 1.33 (0.97-1.82) | |
| EMBRACE | 353 | 378 | 30757 | 16 | 14 | 1318 | 0.70 (0.37-1.32) | |
| Poland | 399 | 285 | 30360 | 28 | 22 | 2197 | 0.98 (0.65-1.47) | |
| kConFab | 322 | 362 | 29568 | 22 | 10 | 1251 | 0.64 (0.34-1.22) | |
| GCHBOC | 157 | 432 | 24819 | 8 | 30 | 1698 | 0.94 (0.65-1.37) | |
| MSKCC | 182 | 268 | 19371 | 5 | 9 | 591 | 0.79 (0.38-1.66) | |
| Ontario | 79 | 217 | 13069 | 14 | 8 | 1012 | 0.33 (0.13-0.82) | |
| LUMC | 129 | 106 | 10350 | 11 | 5 | 715 | 0.68 (0.32-1.44) | |
| Lund | 113 | 102 | 11401 | 7 | 9 | 803 | 1.05 (0.55-1.99) | |
| MOD-SQUAD | 78 | 104 | 7760 | 4 | 6 | 388 | 1.56 (1.04-2.36) | |
| HEBCS | 75 | 108 | 8451 | 4 | 2 | 344 | 0.27 (0.05-1.96) | |
| DKFZ | 61 | 110 | 6714 | 1 | 2 | 109 | 7.05 (0.66-75.2) | |
| MAYO | 41 | 71 | 4998 | 2 | 8 | 442 | 1.41 (0.65-3.07) | |
| INHERIT | 76 | 70 | 6668 | 2 | 3 | 225 | 1.29 (0.45-3.67) | |
| NCI | 157 | 63 | 9371 | 9 | 1 | 433 | 0.28 (0.05-1.77) | |
1
Weighted Cox proportional hazards regression analysis, modeling AURKA F31I as a recessive genotypic effect. Results overall, by menopausal status and by oophorectomy status account for birth cohort, group status, country, and mutation status. Mutation-specific results account for birth cohort, group status and country. Group-specific results account for birth cohort, mutation status and country. Robust variance estimates were used to correct for possible non-independence of study subjects.
*
Cox proportional hazards regression analysis restricted to cases for whom genetic diagnosis is less than three years after breast cancer diagnosis.