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Continuous infusion of MS-275 (100 μm) or SAHA (100 μm) into the NAc significantly increases acetylated H3 in vivo. acH3K14 was quantified directly where the HDAC inhibitor was delivered after 10 continuous days of treatment via immunohistochemistry (A) and Western blotting (B) (*p < 0.01, SAHA; **p < 0.001, MS-275). Error bars indicate SEM.
