Figure 8.

Hsp70 inhibition reduces endogenous and overexpressed tau levels in multiple neuronal models. A, Levels of tau and Hsp70 are shown in cortical murine brain slices from rTg4510 mice (n = 3 slices) and wild-type littermates (n = 3 slices) that were treated with inhibitors (10 μm) or vehicle for 3 h. Black bars indicate MB and gray bars indicate AC as a percentage of vehicle-treated tissue following actin normalization. B, Eight 4-month-old rTg4510 mice injected with 2 μl of 10 mm AC or vehicle were harvested 24 h later. Tau levels were significantly reduced in AC-treated mice (gray bars) relative to vehicle-treated mice (black bars). *p < 0.05 by Student's t test. Actin was used to control for loading in all panels.