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. Author manuscript; available in PMC: 2009 Nov 21.
Published in final edited form as: Circ Res. 2008 Oct 16;103(11):1309–1318. doi: 10.1161/CIRCRESAHA.108.180042

Figure 2. Lats2 partly mediates Mst1-induced apoptosis.

Figure 2

(A) NRCMs were transduced with Ad-LacZ or Ad-DN-Lats2 (DN-L2) at 30 MOI. Twenty-four hours after transduction, myocytes were transduced with Ad-Mst1 at 30MOI. (B) NRCMs were transduced with Ad-LacZ and Ad-DN-Mst1 at 30 MOI. Twenty-four hours after transduction, myocytes were transduced with Ad-Lats2 (L2) at 30 MOI. In A and B, 48 hours after the second transduction, cytoplasmic accumulation of mono- and oligo-nucleosomes was quantitated. Values are mean ± SEM obtained from 3 experiments. N.S., not significant. (C) NRCMs were transduced with Ad-LacZ, Ad-Lats2 or Ad-Mst1 with different combinations (total 60 MOI). Forty-eight hours after the transduction, cytoplasmic accumulation of mono- and oligo-nucleosomes was quantitated. Values are mean ± SEM obtained from 3 experiments. *p<0.05.