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. Author manuscript; available in PMC: 2009 Nov 21.
Published in final edited form as: Circ Res. 2008 Oct 16;103(11):1309–1318. doi: 10.1161/CIRCRESAHA.108.180042

Figure 4. Cardiac Phenotype of Tg-Lats2 mice.

Figure 4

(A) Heart homogenates were prepared from normal mice subjected to either sham operation (sham) or transverse aortic constriction for 2 weeks (TAC), Tg-Lats2 (line 20) or non-transgenic (NTg) littermates, and then immunoblotted with anti-Lats2 and anti-α-actin antibodies. (B) Postmortem measurements of left ventricular weight/tibial length (LVW/TL, left) and right ventricular weight/tibial length (RVW/TL, right) in Tg-Lats2 (line 8) and NTg. Values are mean ± SD. (C) Echocardiographically measured LV end diastolic dimension (LVEDD) and LV ejection fraction (LVEF) in Tg-Lats2 (line 8) and NTg mice. Values are mean ± SEM. (D) Representative WGA staining of the LV and RV myocardium obtained from Tg-Lats2 (line 8) and NTg mice (upper panel) and the relative myocyte cross sectional area (lower panel). Values are mean ± SEM obtained from 5 experiments. *p<0.05.