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. 2009 Nov 13;85(5):569–580. doi: 10.1016/j.ajhg.2009.09.016

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© 2009 The American Society of Human Genetics. Published by Elsevier Ltd. All right reserved..

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Immunohistochemical Analyses of the Accumulated Gb3 in Organs of Fabry Mice and Its Degradation by the Modified NAGA, Agalsidase Beta, and Agalsidase Alfa

Fabry mice were repeatedly injected with the modified NAGA, agalsidase beta, or agalsidase alfa, and then immunostaining for Gb3 was performed. Wild-type, a wild-type mouse; Fabry, an untreated Fabry mouse; Modified NAGA, a Fabry mouse treated with the modified NAGA; Agalsidase beta, a Fabry mouse treated with agalsidase beta; and Agalsidase alfa, a Fabry mouse treated with agalsidase alfa. The scale bar represents 50 μm.