Table 3.

Association of Selected SNPs on 15q25 Loci with Lung Cancer Risk by Decade of Birth in the NCI GWAS

Study	< 1930 (No. of Controls = 1749)			1930–1939 (No. of Controls = 2113)			1940–1949 (No. of Controls = 696)			1950+ (No. of Controls = 190)
	No. of Cases	p Valuea	ORb(95% CI)	No. of Cases	p Valuea	ORb(95% CI)	No. of Cases	p Valuea	ORb(95% CI)	No. of Cases	p Valuea	ORb(95% CI)	PintcSmokAdj
rs12914385
Overall Smok.Unadj	2202	6.94 × 10−8	1.29 (1.18–1.41)	2173	6.94 × 10−12	1.35 (1.24–1.47)	594	2.49 × 10−5	1.42 (1.20–1.66)	155	2.60 × 10−5	1.94 (1.42–2.64)	0.02
Overall Smok.Adjust	2202	1.95 × 10−5	1.25 (1.13–1.38)	2173	5.11 × 10−7	1.28 (1.16–1.41)	594	2.08 × 10−4	1.44 (1.19–1.74)	155	3.91 × 10−4	1.98 (1.36–2.88)	0.04
Adenocarc. Smok.Adjust	541	0.012	1.21 (1.04–1.42)	683	8.33 × 10−5	1.31 (1.15–1.50)	270	0.004	1.42 (1.12–1.80)	84	0.001	2.10 (1.33–3.32)	0.03
Squamous Smok.Adjust	596	6.75 × 10−5	1.36 (1.17–1.58)	582	0.002	1.27 (1.09–1.47)	120	0.096	1.35 (0.95–1.92)	17	0.16	1.75 (0.80–3.85)	0.92
Small Cell Smok.Adjust	268	0.042	1.23 (1.01–1.50)	265	0.002	1.37 (1.12–1.67)	70	0.001	2.02 (1.31–3.09)	15	0.043	2.59 (1.03–6.51)	0.10
rs1051730
Overall Smok.Unadj	2202	9.26 × 10−7	1.27 (1.15–1.39)	2173	2.32 × 10−11	1.35 (1.23–1.47)	594	2.41 × 10−5	1.42 (1.21–1.68)	155	6.75 × 10−6	2.08 (1.51–2.86)	0.009
Overall Smok.Adjust	2202	1.31 × 10−4	1.22 (1.10–1.36)	2173	6.57 × 10−7	1.28 (1.16–1.41)	594	6.89 × 10−4	1.40 (1.15–1.70)	155	8.86 × 10−5	2.18 (1.48–3.23)	0.02
Adenocarc. Smok.Adjust	541	0.011	1.22 (1.04–1.42)	683	7.30 × 10−5	1.32 (1.15–1.51)	270	0.008	1.38 (1.09–1.75)	84	0.002	2.08 (1.30–3.31)	0.05
Squamous Smok.Adjust	596	9.27 × 10−4	1.29 (1.11–1.51)	582	0.002	1.26 (1.09–1.47)	120	0.32	1.20 (0.84–1.72)	17	0.053	2.23 (0.99–5.05)	0.79
Small Cell Smok.Adjust	268	0.11	1.18 (0.96–1.44)	265	0.002	1.38 (1.13–1.70)	70	7.02 × 10−4	2.12 (1.37–3.28)	15	0.018	3.23 (1.22–8.53)	0.02
rs8034191
Overall Smok.Unadj	2202	1.13 × 10−5	1.23 (1.12–1.35)	2173	2.60 × 10−8	1.23 (1.12–1.35)	594	2.70 × 10−5	1.42 (1.20–1.67)	155	1.10 × 10−5	2.01 (1.47–2.74)	0.007
Overall Smok.Adjust	2202	0.002	1.18 (1.06–1.30)	2173	5.67 × 10−5	1.22 (1.11–1.35)	594	5.73 × 10−4	1.40 (1.16–1.70)	155	1.56 × 10−4	2.09 (1.43–3.06)	0.01
Adenocarc. Smok.Adjust	541	0.13	1.13 (0.96–1.31)	683	0.001	1.25 (1.09–1.43)	270	0.002	1.45 (1.14–1.84)	84	0.005	1.92 (1.22–3.02)	0.01
Squamous Smok.Adjust	596	0.006	1.23 (1.06–1.43)	582	0.007	1.23 (1.06–1.43)	120	0.39	1.17 (0.82–1.67)	17	0.064	2.04 (0.96–4.35)	0.67
Small Cell Smok.Adjust	268	0.24	1.13 (0.92–1.38)	265	0.005	1.33 (1.09–1.63)	70	0.004	1.89 (1.23–2.91)	15	0.039	2.60 (1.05–6.44)	0.05

Most notable SNPs from the NCI GWAS and SNPs identified as relevant for lung cancer risk in previous studies are shown. The lung cancer cases in the Overall analyses include adenocarcinomas, squamous cell carcinomas, small cell carcinomas, and other groups of different histologic types or mixed histologies. Smoking Unadjusted results are adjusted for age in five-year intervals (defined as age-at-diagnosis/interview for case-control study and age at baseline for cohort study), gender, study (EAGLE, PLCO, ATBC, CPS-II), decade of birth (<1930, 1930–1940, 1940+, MISSING) and four principal components for population stratification within studies (two for PLCO, and one each for EAGLE and ATBC). Smoking Adjusted, results are adjusted for the same variables as above plus smoking status (current, former, never), cigarettes smoked per day (≤10, 11–20, 21–30, 31–40, 41+), duration in ten-year intervals and number of years since quitting (1–5, 6–10, 11–20, 21–30, 30+) for former smokers.

^a1 d.f. Wald test.

^bOR, per-allele odds ratio; CI, 95% confidence interval.

^cP-value of interaction between SNPs and decade of birth in the association with lung cancer risk overall and in each histology stratum. 1d.f. Wald test (decade of birth coded as 0,1,2,3).