Table 1.

Transmission of Ka/scrapie in wild-type ICR mice

First passage (16/16a)			Second passage			Third passage
15/16b	457 ± 21.1c	→	5/5	255.8 ± 28.8	→	10/10	151.5 ± 5.6
1/16d	469	→	5/5	287.0 ± 6.5	→	10/10	272.3 ± 29.0

^aNumber of infected mice/number of inoculated mice

^bMice exhibiting weight loss and hind-limb ataxia. All of these mice showed the same clinical signs and same neuropathological phenotype. The brain homogenate of 1 of the 15 mice was used for the second passage (incubation period, 463 days)

^cAverage ± standard deviation (days)

^dA single mouse exhibiting polydipsia, polyuria, and obesity