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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):319–326. doi: 10.1002/jbm.b.31289

Figure 4.

Figure 4

Antagonists of TNFα activity retain in vitro bioactivity following release from chitosan-GP gels (ANOVA, p < 0.01). Exposure of murine L929 fibrosarcoma cells to 0.25 ng/mL TNFα leads to a profound decrease (*, Dunn’s, α = 0.05) in cell survival (mean ± s.e.m., n = 8). Cytoprotection was observed when cells were treated with supernatant containing curcumin, anti-TNF antibody, sTNFRII released from these gels (#). This protective effect was not observed upon coincubation with BSA-containing supernatant released from BSA-loaded chitosan-GP gels.