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. 2009 Oct 1;23(11):1914–1926. doi: 10.1210/me.2009-0242

Figure 3.

Figure 3

Effect of somatostatin- and hepatocyte-specific STAT5a/STAT5b deficiency on mouse liver Bcl6 mRNA. RNA isolated from individual mouse livers was analyzed by qPCR for expression of Bcl6. Bcl6 mRNA levels were normalized to the 18S rRNA content of each sample and expressed relative to the average level in wild-type (WT) males, which was set to 1. Data shown are mean ± se for each group. A, Bcl6 mRNA was determined in livers of WT (Smst+/+) male (n = 11) and female (n = 8) mice and somatostatin-deficient (KO; Smst−/−) male (n = 13) and female (n = 14) mice. B, Bcl6 RNA was determined in livers of WT (Stat5a/Stat5b-flox) male and female mice and in Stat5a/Stat5b-deficient (KO) male and female mice (n = 8 per group). Data were analyzed using one-way ANOVA with Tukey post hoc test: ** and ***, P < 0.01 and P < 0.001, respectively, for male vs. corresponding female group; +++, P < 0.001, for WT vs. KO. Down-regulation of Bcl6 in Smst-KO female did not reach statistical significance. KO, Knockout.