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Pref-1 inhibition of adipogenesis. Membrane-bound Pref-1A and Pref-1B generate 50-kDa soluble Pref-1 by TACE-mediated cleavage at the juxtamembrane region. Binding of the 50-kDa soluble Pref-1 to the putative Pref-1 receptor at the preadipocyte membrane activates MEK/ERK which, in turn, increases Sox9 expression. Sox9 binds to its binding sites at the C/EBPβ and C/EBPδ promoter regions to suppress their transcription, resulting in inhibition of adipocyte differentiation.
