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. 2009 Nov 20;4(11):e7932. doi: 10.1371/journal.pone.0007932

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Santagata et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Immunohistochemistry for CRX in tumors frequently considered in the differential diagnosis of pineoblastoma including atypical teratoid rhabdoid tumor (ATRT) (A, B), CNS germinoma (C, D) and primitive neuroectodermal tumor (PNET) (E, F) reveals an absence of staining. Immunostaining for CRX in classic medulloblastoma reveals heterogeneous intranuclear staining in scattered cells in a subset of tumors (G, H). Original magnification, 400x.