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. 2009 Nov 20;4(11):e7937. doi: 10.1371/journal.pone.0007937

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Mabon et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Genetic background of strains is indicated by closed (wild type - N2) or open bars (mutant – either daf-2(e1368) or daf-16(mu86)). Note that survival data are after a 22 hour hypoxic incubation for the upper and lower panels and are after a 24 hour hypoxic incubation for the middle panel. (A) Survival after recovery from a 22 hour hypoxic incubation for N2 wild type animals treated with bacteria transfected with L4440 empty vector or with RNAi plasmids against die genes. * p<0.01 compared to L4440 (two-tailed t-test, 6 trials/RNAi with >30 worms/trial). (B) Effect of RNAi treatments on survival after a 24 hour hypoxic incubation in wild type and daf-2(e1368) backgrounds. All RNAi's resistance in an e1368 background compared to L4440 – p<0.01 (two-tailed t-test, 3 trials/RNAi with >30 worms/trial) (C) Effect of RNAi treatments on survival after a 22 hour hypoxic incubation in wild type and daf-16(mu86 null) backgrounds. Hypoxia resistance significantly suppressed in mu86 background for all RNAi's – p<0.01 (paired t-test, 6 trials/RNAi with >30 worms/trial).