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. 2009 Oct 9;150(11):4855–4862. doi: 10.1210/en.2009-0708

Figure 2.

Figure 2

The adverse effect of STZ treatment is ameliorated in wt-GPx(+) mice. A, Nonfasting plasma glucose levels were significantly greater after multiple low-dose STZ treatment in male wt-GPx(−) (▪, n = 5) compared with wt-GPx(+) (•, n = 7) mice. *, P < 0.003. Levels in both genotypes were higher than those observed in non-STZ-treated male wt-GPx(−) (▴, n = 8) and wt-GPx(+) (♦, n = 6) mice. B, Immunohistochemistry of islets from STZ-treated mice. Double immunostaining for insulin (green) and MafA (red, first set of panels) and PDX-1 (red, second set of panels) in islets from wt-GPx(−) and wt-GPx(+) mice 8 wk after STZ treatment. The marked changes in wt-GPx(−) animals were not observed in wt-GPx(+) animals (magnification, ×80 for the wt-GPx(−) PDX-1 image and ×40 for all other images; bar, 50 μm).