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. 2009 Oct 9;150(11):4855–4862. doi: 10.1210/en.2009-0708

Figure 4.

Figure 4

Hyperglycemia was reduced and nearly normalized in db/db-GPx(+) mice. A, Plasma glucose levels were measured weekly in the nonfasted state from 4 to 20 wk of age in db/db-GPx(−) (▪, n = 19), db/db-GPx(+) (•, n = 13), wt-GPx(−) (▴, n = 14), and wt-GPx(+) (♦, n = 11) mice. The mean peak glucose value in db/db-GPx(+) animals occurred at 10 wk of age and was significantly lower than the 10-wk value in db/db-GPx(−) animals. *, P < 0.009. The glucose value at the end of the study (20 wk) was also significantly different. **, P < 0.0001. Additionally, the levels for db/db-GPx(+) animals significantly declined from 10 to 20 wk of age (P < 0.04). B, Body weights were measured weekly. At 20 wk of age, body weights of db/db-GPx(−) mice (▪) did not differ from db/db-GPx(+) mice (•); however, both groups of db/db mice had greater weights than wt-GPx(−) (▴) and wt-GPx(+) (♦) mice. *, P < 0.0001.