Figure 1.

Lgr5 is spatiotemporally expressed in the uterus as determined by in situ hybridization. A, Lgr5 is highly expressed in luminal and glandular epithelia of immature and pubertal mice at 10, 21, and 30 d after birth. B, Lgr5 expression pattern is altered by the stage of estrous cycle. Positive signals are evident in metestrus and diestrus uteri. C, Lgr5 is expressed in epithelial cells on d 1 of pregnancy. On d 5, Lgr5 expression is absent at the implantation site (cross-section) but present in epithelial cells at the interimplantation site (longitudinal section). le, Luminal epithelium; ge, glandular epithelium; myo, myometrium; em, embryo.