Figure 5.

Aberrant Wnt signaling disrupts Lgr5 expression. A, Canonical Wnt signaling is activated in uteri at different ages. Blue color represents expression of LacZ triggered by canonical Wnt signaling. B, Persistent or diminished Wnt signaling down-regulates Lgr5 expression. Lgr5 mRNA levels are down-regulated by heightened Wnt signaling in Ctnnb1^{d(ex3)/d(ex3)} uteri. Elimination of canonical Wnt signaling by conditional deletion of uterine Ctnnb1 dramatically down-regulates Lgr5 mRNA levels. le, Luminal epithelium.