Table 2.
Variables identified by stepwise logistic regression models as associated with death/BPD. Variables were allowed to enter/stay in the model at p<0.2
| Full data set | ||
|---|---|---|
| Stepwise logistic regression |
Variables added | Odds ratio ( 95% CI ) |
| First Step | Birth weight (per 100g) | 0.78 (0.71 – 0.85) |
| Second Step | Mean FiO2 | 3.14 (0.72 – 13.63) |
| Third Step | Male gender | 2.54 (150 – 4.28) |
| Fourth Step | Surfactant dose | 1.44 (1.06 – 1.96) |
| Fifth Step | Mean OI (per unit) | 1.03 (1.00 – 1.05) |
| Sixth Step | Outborn | 1.73 (0.91 – 3.30) |
| c statistic for model = 0.75 | ||
| Treatment (iNO) group | ||
|---|---|---|
| Stepwise logistic regression |
Variables added | Odds ratio (95% CI) |
| First Step | Birth weight (per 100g) | 0.65 (0.56 – 0.76) |
| Second Step | Mean FiO2 | 26.54 (3.88 – 181.48) |
| Third Step | Age at randomization (hours) | 0.97 (0.96 – 0.99) |
| Fourth Step | Surfactant dose | 2.21 (1.27 – 3.84) |
| Fifth Step | Seizures | 0.28 (0.04 – 1.85) |
| c statistic for model = 0.84 | ||
| Control group | ||
|---|---|---|
| Stepwise logistic regression |
Variables added | Odds ratio (95% CI) |
| First Step | Male gender | 4.67 (2.13 – 10.27) |
| Second Step | Gestational age (per week) | 0.86 (0.73 – 1.02) |
| Third Step | High frequency ventilation | 0.39 (0.18 – 0.86) |
| Fourth Step | Outborn | 2.34 (0.91 – 6.04) |
| Fifth Step | Air Leak | 0.33 (0.11 – 0.96) |
| Sixth Step | Mean OI (per unit) | 1.02 (0.99 – 1.05) |
| Seventh Step | Change in PaO2 (baseline to 5 ppm study gas) |
0.98 (0.96 – 1.00) |
| Eighth Step | PaO2 Max Diff | 1.02 (1.00 – 1.04) |
| c statistic for model = 0.76 | ||