TABLE IV.
21 Stable apoptosis genes in vivo are previously reported in HIV-1-exposed/infected M/Ma
| Accession No. | Gene Symbol | Gene Name | Reference to Previous HIV-1 Report(s) |
|---|---|---|---|
| N63940 | ACHE | Acetylcholinesterase (YT blood group) | (38) |
| AA683578 | ADA | Adenosine deaminase | (38) |
| AA455941 | APEH | N-acylaminoacyl-peptide hydrolase | (38) |
| AA425102 | CCL2 | Chemokine (C-C motif) ligand 2 | (18, 37–39, 77) |
| AA101971 | ETS1 | V-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | (38) |
| AA410375 | GMPR | Guanosine monophosphate reductase | (38) |
| H50114 | GRIN2C | Glutamate receptor, ionotropic, N-methyl-D-aspartate 2C | (38) |
| T80846 | HAAO | 3-Hydroxyanthranilate-3,4-dioxygenase | (38) |
| AA457705 | IER3 | Immediate early response 3 | (39) |
| AI870374 | LDOC1 | Leucine zipper, down-regulated in cancer 1 | (38) |
| R83837 | LYN | V-yes-1 Yamaguchi sarcoma viral-related oncogene homolog | (24, 39) |
| H86558 | MAD | MAX dimerization protein 1 | (38) |
| NM_012219 | MRAS | Muscle RAS oncogene homolog | (38) |
| AA872383 | MT1E | Metallothionein 1E (functional) | (38) |
| N55459 | MT1F | Metallothionein 1F (functional) | (38) |
| H77597 | MT1H | Metallothionein 1H | (38) |
| AA446246 | NRAS | Neuroblastoma RAS viral (v-ras) oncogene homolog | (39) |
| AI952615 | p21 | CDKN1A/Waf1/Cip1/Sdi1 | (39) |
| AA258001 | RELB | V-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of κ light polypeptide gene enhancer in B cells 3 (avian) | (38) |
| AI473336 | WISP1 | WNT1 inducible signaling pathway protein 1 | (37) |
| AA425900 | UNG2 | Uracil-DNA glycosylase 2 | (41, 42) |
a
Indicated are the accession numbers, gene symbols, and gene names for 21 genes from the stable apoptosis signature that we identify in in vivo HIV-1 monocytes that have also been previously reported as modulated in in vitro macrophages by HIV-1. The references for previous studies that have reported HIV-1-associated modulation of these genes are additionally provided.