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. Author manuscript; available in PMC: 2009 Nov 11.
Published in final edited form as: J Immunol. 2008 Oct 15;181(8):5433–5441. doi: 10.4049/jimmunol.181.8.5433

FIGURE 5.

FIGURE 5

Loss-of-function of XBP-1 results in diminished KLRG1high effector CD8+ T cell population. A, OT-I/RAG1−/− CD8+ T cells were transduced with a dominant negative form of XBP-1 (dnXBP-1) and transferred to host mice, followed by infection with LM-OVA. KLRG1 levels on the transduced cells (day 7 p.i.) in the blood are shown. Graphic representation of mean fluorescence intensity (MFI) of KLRG1 (right). Results indicate the mean ± SEM (n = 5 mice each). B, WT or XBP-1−/− bone marrow chimeric mice were infected with LCMV. On day 8, gp33-specific CD8+ T cells in the blood were detected by tetramer staining. Percentage of Dbgp33 tetramer-positive within the donor CD8+ population (top) gated on CD229.1+ donor bone marrow-derived CD8+ cells is shown. KLRG1 and CD127 levels on gp33-specific CD8+ T cells are shown. The percentage within the donor gp33-specific CD8+ T cells (bottom) is indicated. C, Graphic representation of data in B with the mean ± SEM for n = 8–10 mice.